Spectrum of Resistance Mechanisms to ALK TKIs in NSCLC: Largest Single-Center Experience from India

Spectrum of Resistance Mechanisms to ALK TKIs in NSCLC: Largest Single-Center Experience from India

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Introduction Anaplastic lymphoma kinase (ALK) rearranged non-small cell lung carcinoma Pad (NSCLC) has emerged as a distinct entity with growing number of potent ALK tyrosine kinase inhibitors (TKIs).Despite showing durable responses and promising survival rates, resistance to these ensue.This is the largest series of repeat biopsies from patients of ALK-positive NSCLC progressing on ALK-directed therapy from this part of the 02 Sensor world.

Using a combinatorial approach of genomics and histology, we describe the spectrum of various resistance mechanisms encountered.